You are allergic to tolterodine tartrate extended-release capsules or to any of their ingredients. See the end of this leaflet for a complete list of ingredients. GJ, Roden DM, Zareba W. Prevention of torsade de pointes in hospital settings: a scientific statement from the American Heart Association and the American College of Cardiology Foundation. WebMD. Working women tell him they have to leave twice during an hour and a half meeting to go to the bathroom. hemob.info nifedipine
The 2 mg capsules are light green with “7163” imprinted on the body and “TEVA” imprinted on the cap. Tolterodine acts as a competitive antagonist of acetylcholine at postganglionic muscarinic receptors. Both urinary bladder contraction and salivation are mediated via cholinergic muscarinic receptors. Parameter was dose-normalized from 4 mg to 2 mg. not applicable. It's also important to eat high-fiber foods, because may worsen the symptoms of syndrome. Appell RA. Clinical efficacy and safety of tolterodine in the treatment of overactive bladder: a pooled analysis. Urology.
Van Kerrebroeck P, Kreder K, Jonas U et al. Tolterodine once-daily: superior efficacy and tolerability in the treatment of overactive bladder. Urology. Netupitant: May increase the serum concentration of CYP3A4 Substrates. National Institute of Diabetes and Digestive and Kidney Diseases: "Prostate Enlargement: Benign Prostatic Hyperplasia.
The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist. Detrol LA tolterodine tartrate US prescribing information. online pharmacy buy olanzapine usa
Know the medicines you take. Keep a list of them with you to show your doctor or pharmacist each time you get a new medicine. Protect ER capsules from light. Tiotropium: Anticholinergic Agents may enhance the anticholinergic effect of Tiotropium. DETROL LA and get emergency medical help right away. Plan ahead to locate public restrooms. For example, the National Association for Continence web site has a tool called "Find a Bathroom. Asunaprevir: May increase the serum concentration of CYP2D6 Substrates. The two often coexist in women. DETROL LA is right for you. Medicines are sometimes prescribed for conditions that are not in the patient information leaflet. Use with caution in patients receiving therapy for angle-closure glaucoma. It belongs to a class of drug called anticholinergics. It is the first of this class to go over-the-counter for overactive bladder treatment. These may be symptoms of heart failure. This occurs uncommonly occurs in less than 1 in 100 patients. Are you experiencing other symptoms?
DETROL LA 4 mg capsule for oral administration contains 4 mg of tolterodine tartrate. If you miss a dose of Detrol, just take your next regular dose at your next regular time. Do not try to make up for your missed dose. Overactive happens when you cannot control your bladder muscle. Variability in Metabolism: A subset of individuals approximately 7% of Caucasians and approximately 2% of African Americans are poor metabolizers for CYP2D6, the enzyme responsible for the formation of 5-HMT from tolterodine. The identified pathway of metabolism for these individuals “poor metabolizers” is dealkylation via cytochrome P450 3A4 CYP3A4 to N-dealkylated tolterodine. The remainder of the population is referred to as “extensive metabolizers. Detrol Tablets 2 mg was treated with a suspension of activated charcoal and was hospitalized overnight with symptoms of dry mouth. The child fully recovered. Overactive bladder is caused by an overactive muscle in the bladder that pushes urine out. There are many things that can make this muscle overactive. Madewell KA, Kuo P. Hyponatremia associated with tolterodine therapy. Am J Health Syst Pharm. Tolterodine immediate release does not cause clinically significant interactions with other drugs metabolized by the major drug metabolizing CYP enzymes. In vivo drug-interaction data show that tolterodine immediate release does not result in clinically relevant inhibition of CYP1A2, 2D6, 2C9, 2C19, or 3A4 as evidenced by lack of influence on the marker drugs caffeine, debrisoquine, S-warfarin, and omeprazole. pristiq
External urethral barrier: A self-adhesive patch you can put over the opening where urine comes out. Patients should be informed that antimuscarinic agents such as Detrol may produce the following effects: blurred vision, dizziness, or drowsiness. Patients should be advised to exercise caution in decisions to engage in potentially dangerous activities until the drug's effects have been determined. This medicine has been prescribed for you. Do not pass it on to others. May increase tolterodine plasma levels, which may increase activity and adverse effects. During coadministration with potent CYP3A4 inhibitors, the recommended dosage of immediate-release tolterodine is 1 mg twice daily and the recommended dosage of ER tolterodine is 2 mg once daily. If you miss a dose of tolterodine tartrate extended-release capsules, begin taking tolterodine tartrate extended-release capsules again the next day. Do not take 2 doses of tolterodine tartrate extended-release capsules in the same day. Tolterodine belongs to the group of medicines called antispasmodics. It helps decrease muscle spasms of the bladder and the frequent urge to urinate caused by these spasms. Use Detrol as directed by your doctor. Check the label on the medicine for exact dosing instructions. In people with overactive bladder, muscles in the bladder wall contract at the wrong time. Swallow mirabegron whole with water. Do not break, crush, or chew before swallowing. Remember to pack your medications in your carry-on luggage. Also bring along a copy of your prescription, Griebling says. The need to urinate often. Absorbent products such as mini-shields that attach to underwear or plastic-backed diapers. These items help you guard against accidents. Most of them are disposable, but you can also buy absorbent cloths that you can wash and reuse. RimabotulinumtoxinB: Anticholinergic Agents may enhance the anticholinergic effect of RimabotulinumtoxinB. Tolterodine plasma concentrations may be increased. The recommended dosage of immediate-release tolterodine is 1 mg twice daily during coadministration. Ask your doctor about adjustments in that can affect urine output. Taking diuretics at a different time of day, for instance, might help.
Blurred vision; constipation; dizziness; drowsiness; dry eyes; dry mouth; headache; indigestion; stomach pain. CYP3A4 Inducers Strong: May increase the metabolism of CYP3A4 Substrates. Management: Consider an alternative for one of the interacting drugs. Some combinations may be specifically contraindicated. Consult appropriate manufacturer labeling. Importance of informing patients of other important precautionary information. See Cautions. QT trials of other drugs. If you are breastfeeding. It is not known if Detrol passes into your breast milk or if it can harm your baby. Talk to your doctor about the best way to feed your baby if you take Detrol. If you took more than your prescribed dose of tolterodine tartrate extended-release capsules, call your doctor or poison control center, or go to the hospital emergency room. It is not known whether tolterodine is excreted in human milk; therefore, tolterodine tartrate extended-release capsules should not be administered during nursing. A decision should be made whether to discontinue nursing or to discontinue tolterodine tartrate extended-release capsules in nursing mothers. QT prolongation: Has been associated with QT c prolongation at high supratherapeutic doses. The manufacturer recommends caution in patients with congenital prolonged QT or in patients receiving concurrent therapy with QT c-prolonging drugs class Ia or III antiarrhythmics. However, the extent of QT c prolongation even at supratherapeutic dosages was less than 15 msec. Individuals who are CYP2D6 poor metabolizers or in the presence of inhibitors of CYP2D6 and CYP3A4 may be more likely to exhibit prolongation. Ruscin JR, Morgenstern NE. Tolterodine use for symptoms of overactive bladder. Ann Pharmacother. An extra patient leaflet is available with Detrol. Talk to your pharmacist if you have questions about this information. Thus, tolterodine exposure in the carcinogenicity studies was 9- to 14-fold higher than expected in humans. No increase in tumors was found in either mice or rats. Angioedema: Cases of angioedema have been reported; some cases have occurred after a single dose. Discontinue immediately if angioedema and associated difficulty breathing, airway obstruction, or hypotension develop. Following oral administration, approximately 77 and 17% of administered dose was recovered within 7 days in urine and feces, respectively, principally within the first 24 hours. Tolterodine Tartrate Tablets, like other antimuscarinic drugs, should be used with caution in patients with decreased gastrointestinal motility. Of the 1120 patients who were treated in the four Phase 3, 12-week clinical studies of Detrol, 474 42% were 65 to 91 years of age. mail order cheap betamethasone canada
Fortunately, there are ways to combat the problem. April 9, 2012 -- Drugs that treat caused by an offer modest benefits to some women, and they often come with significant side effects, a new review of research shows. Take this medicine only as directed. Do not take more of it, do not take it more often, and do not take it for a longer time than your doctor ordered. To do so may increase the chance of side effects. Also, do not change your dose without checking first with your doctor. Your stomach empties slowly also called “gastric retention”. Symptoms may include fast or irregular heartbeat; severe or persistent headache or dizziness. The pharmacokinetics of tolterodine extended-release capsules have been evaluated in pediatric patients ranging in age from 11 to 15 years. The dose-plasma concentration relationship was linear over the range of doses assessed. Overdosage with tolterodine tartrate extended-release capsules can potentially result in severe central anticholinergic effects and should be treated accordingly. Distributed into milk in mice; 1 2 23 not known whether tolterodine crosses the placenta or is distributed into human milk. Aclidinium: May enhance the anticholinergic effect of Anticholinergic Agents.
Anon. Tolterodine for overactive bladder. Med Lett Drugs Ther. When you live with your overwhelming worry becomes, "Where is the nearest bathroom? Yet with proper management and trip preparations, you can travel with less fear of toileting accidents. Moderate Risk QTc-Prolonging Agents: QTc-Prolonging Agents Indeterminate Risk and Risk Modifying may enhance the QTc-prolonging effect of Moderate Risk QTc-Prolonging Agents. Tolterodine Tartrate Tablets are indicated for the treatment of overactive bladder with symptoms of urge urinary incontinence, urgency, and frequency. Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take. While using this product, do not start, stop, or change the dosage of any other medicines you are using without your doctor's approval. Detrusitol is used for the treatment of the symptoms of overactive bladder syndrome. Stahl MMS, Ekström B, Sparf B et al. Urodynamic and other effects of tolterodine: a novel antimuscarinic drug for the treatment of detrusor overactivity. Neurourol Urodyn. Visiting your doctor for a thorough evaluation and following his or her instructions carefully can help you get the OAB treatment you need to get back into your old routine. aldactone order now online usa
What should I avoid while taking DETROL? Use is not recommended; has not been studied. Bosentan: May decrease the serum concentration of CYP3A4 Substrates. DETROL LA can be taken with or without food. Tolterodine may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert. Both men and women can have it, but it's more common in women. CYP2D6 extensive metabolizers had low serum concentrations of tolterodine and high concentrations of the active metabolite 5-HMT, while poor metabolizers had high concentrations of tolterodine and negligible active metabolite concentrations. Stiripentol: May increase the serum concentration of CYP3A4 Substrates. Management: Use of stiripentol with CYP3A4 substrates that are considered to have a narrow therapeutic index should be avoided due to the increased risk for adverse effects and toxicity. Any CYP3A4 substrate used with stiripentol requires closer monitoring. The classifications below are a general guideline only. It is difficult to determine the relevance of a particular drug interaction to any individual given the large number of variables. At night, if you have trouble getting to the toilet in time, clear a path from your bed to the bathroom. Or you could put a portable toilet by your bed. Patient may experience fatigue, headache, blurred vision, abdominal pain, heartburn, constipation, dry mouth, or dry eyes. Have patient report immediately to prescriber shortness of breath, severe dizziness, passing out, confusion, urinary retention, or painful urination HCAHPS.
CYP2D6, the enzyme responsible for the formation of the 5-hydroxymethyl metabolite of tolterodine. The identified pathway of metabolism for these individuals “poor metabolizers” is dealkylation via cytochrome P450 3A4 CYP3A4 to N-dealkylated tolterodine. The remainder of the population is referred to as “extensive metabolizers. Those with the condition worry about accidents, the researchers say, and can feel depressed and hopeless. The state of mind is worse for those with "wet" overactive bladder than "dry. The effect of 200 mg daily dose of ketoconazole on the pharmacokinetics of tolterodine immediate-release was studied in 8 healthy volunteers, all of whom were poor metabolizers see for discussion of poor metabolizers. The new study is published in the Annals of Internal Medicine. It was funded by the federal Agency for Research and Quality. Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed. Consult your or local waste disposal company. Tolterodine tartrate extended-release capsules may cause allergic reactions that may be serious. Symptoms of a serious allergic reaction may include swelling of the face, lips, throat, or tongue. If you experience these symptoms, you should stop taking tolterodine tartrate extended-release capsules and get emergency medical help right away. Gosselin RE, Smith RP, Hodge HC et al. Clinical toxicology of commercial products. Ultrasonography. A diagnostic imaging test using sound waves to visualize an internal body structure. Do your Kegels. Strengthening your pelvic muscles with can help prevent urine leakage. Tolterodine tartrate extended-release capsules, 2 mg were evaluated in 29 patients in a Phase 2 dose-effect study. Tolterodine tartrate extended-release capsules, 4 mg were evaluated for the treatment of overactive bladder with symptoms of urge urinary incontinence and frequency in a randomized, placebo-controlled, multicenter, double-blind, Phase 3, 12 week study. A total of 507 patients received tolterodine tartrate extended-release capsules, 4 mg once daily in the morning and 508 received placebo. The majority of patients were Caucasian 95% and female 81% with a mean age of 61 years range, 20 to 93 years. In the study, 642 patients 42% were 65 to 93 years of age. The study included patients known to be responsive to tolterodine immediate release and other anticholinergic medications, however, 47% of patients never received prior pharmacotherapy for overactive bladder. At study entry, 97% of patients had at least 5 urge incontinence episodes per week and 91% of patients had 8 or more micturitions per day. torsemide
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Renal impairment can significantly alter the disposition of tolterodine and its metabolites. Take tolterodine tartrate extended-release capsules once a day with liquid. Swallow the whole capsule. Tell your doctor if you cannot swallow a capsule. Patients should be informed that antimuscarinic agents such as Tolterodine Tartrate Tablets may produce the following effects: blurred vision, dizziness, or drowsiness. Patients should be advised to exercise caution in decisions to engage in potentially dangerous activities until the drug's effects have been determined. Another option is electrical stimulation to stimulate the sacral nerves that help control the bladder and its sphincter muscles. This treatment is not well studied but is considered safe. In one study reported in the British Medical Journal in 2000, nearly half of people using electrical stimulation reported improvement. esomeprazole
Effect of tolterodine on other drugs metabolized by Cytochrome P450 enzymes: Tolterodine immediate release does not cause clinically significant interactions with other drugs metabolized by the major drug-metabolizing CYP enzymes. In vivo drug-interaction data show that tolterodine immediate release does not result in clinically relevant inhibition of CYP1A2, 2D6, 2C9, 2C19, or 3A4 as evidenced by lack of influence on the marker drugs caffeine, debrisoquine, S-warfarin, and omeprazole. In healthy volunteers, coadministration of tolterodine immediate-release 4 mg 2 mg bid for 7 days and a single dose of warfarin 25 mg on day 4 had no effect on prothrombin time, Factor VII suppression, or on the pharmacokinetics of warfarin.
Tolterodine tartrate is a white, crystalline powder. If you haven't used these drugs before and want to try them, Griebling suggests you start taking them a few weeks before your trip. Upjohn, Kalamazoo, MI: Personal communication. The data described below reflect exposure to Tolterodine Tartrate Tablets 2 mg bid in 986 patients and to placebo in 683 patients exposed for 12 weeks in five Phase 3, controlled clinical studies. Because clinical trials are conducted under widely varying conditions, adverse reaction rates observed in the clinical trials of a drug cannot be directly compared to rates in the clinical trials of another drug and may not reflect the rates observed in practice. The adverse reaction information from clinical trials does, however, provide a basis for identifying the adverse events that appear to be related to drug use and approximating rates. reminyl purchase over the counter
PO 2 mg twice daily; lower dosage to 1 mg twice daily based on individual response and tolerability. The need to drop everything and race to the bathroom can disrupt your life. And if you leak, even if it's only a little bit, it can be embarrassing. DETROL Tablets contain tolterodine tartrate.